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Abstract Objective.Optogenetics allows the manipulation of neural circuitsin vivowith high spatial and temporal precision. However, combining this precision with control over a significant portion of the brain is technologically challenging (especially in larger animal models).Approach.Here, we have developed, optimised, and testedin vivo, the Utah Optrode Array (UOA), an electrically addressable array of optical needles and interstitial sites illuminated by 181μLEDs and used to optogenetically stimulate the brain. The device is specifically designed for non-human primate studies.Main results.Thinning the combinedμLED and needle backplane of the device from 300μm to 230μm improved the efficiency of light delivery to tissue by 80%, allowing lowerμLED drive currents, which improved power management and thermal performance. The spatial selectivity of each site was also improved by integrating an optical interposer to reduce stray light emission. These improvements were achieved using an innovative fabrication method to create an anodically bonded glass/silicon substrate with through-silicon vias etched, forming an optical interposer. Optical modelling was used to demonstrate that the tip structure of the device had a major influence on the illumination pattern. The thermal performance was evaluated through a combination of modelling and experiment, in order to ensure that cortical tissue temperatures did not rise by more than 1 °C. The device was testedin vivoin the visual cortex of macaque expressing ChR2-tdTomato in cortical neurons.Significance.It was shown that the UOA produced the strongest optogenetic response in the region surrounding the needle tips, and that the extent of the optogenetic response matched the predicted illumination profile based on optical modelling—demonstrating the improved spatial selectivity resulting from the optical interposer approach. Furthermore, different needle illumination sites generated different patterns of low-frequency potential activity. 

Abstract Flare-associated quasiperiodic pulsations (QPPs) in radio and X-ray wavelengths, particularly those related to nonthermal electrons, contain important information about the energy release and transport processes during flares. However, the paucity of spatially resolved observations of such QPPs with a fast time cadence has been an obstacle for us to further understand their physical nature. Here, we report observations of such a QPP event that occurred during the impulsive phase of a C1.8-class eruptive solar flare using radio imaging spectroscopy data from the Karl G. Jansky Very Large Array (VLA) and complementary X-ray imaging and spectroscopy data. The radio QPPs, observed by the VLA in the 1–2 GHz with a subsecond cadence, are shown as three spatially distinct sources with different physical characteristics. Two radio sources are located near the conjugate footpoints of the erupting magnetic flux rope with opposite senses of polarization. One of the sources displays a QPP behavior with a ∼5 s period. The third radio source, located at the top of the postflare arcade, coincides with the location of an X-ray source and shares a similar period of ∼25–45 s. We show that the two oppositely polarized radio sources are likely due to coherent electron cyclotron maser emission. On the other hand, the looptop QPP source, observed in both radio and X-rays, is consistent with incoherent gyrosynchrotron and bremsstrahlung emission, respectively. We conclude that the concurrent, but spatially distinct QPP sources must involve multiple mechanisms which operate in different magnetic loop systems and at different periods. 

Abstract Even small solar flares can display a surprising level of complexity regarding their morphology and temporal evolution. Many of their properties, such as energy release and electron acceleration can be studied using highly complementary observations at X-ray and radio wavelengths. We present X-ray observations from the Reuven Ramaty High Energy Solar Spectroscopic Imager and radio observations from the Karl G. Jansky Very Large Array (VLA) of a series of GOES A3.4–B1.6 class flares observed on 2013 April 23. The flares, as seen in X-ray and extreme ultraviolet, originated from multiple locations within active region NOAA 11726. A veritable zoo of different radio emissions between 1 GHz and 2 GHz was observed cotemporally with the X-ray flares. In addition to broadband continuum emission, broadband short-lived bursts and narrowband spikes, indicative of accelerated electrons, were observed. However, these sources were located up to 150″ away from the flaring X-ray sources but only some of these emissions could be explained as signatures of electrons that were accelerated near the main flare site. For other sources, no obvious magnetic connection to the main flare site could be found. These emissions likely originate from secondary acceleration sites triggered by the flare, but may be due to reconnection and acceleration completely unrelated to the cotemporally observed flare. Thanks to the extremely high sensitivity of the VLA, not achieved with current X-ray instrumentation, it is shown that particle acceleration happens frequently and at multiple locations within a flaring active region. 

Titanium is one of the most abundant elements in the earth’s crust and while there are many examples of its bioactive properties and use by living organisms, there are few studies that have probed its biochemical reactivity in physiological environments. In the cosmetic industry, TiO2 nanoparticles are widely used. They are often incorporated in sunscreens as inorganic physical sun blockers, taking advantage of their semiconducting property, which facilitates absorbing ultraviolet (UV) radiation. Sunscreens are formulated to protect human skin from the redox activity of the TiO2 nanoparticles (NPs) and are mass-marketed as safe for people and the environment. By closely examining the biological use of TiO2 and the influence of biomolecules on its stability and solubility, we reassess the reactivity of the material in the presence and absence of UV energy. We also consider the alarming impact that TiO2 NP seepage into bodies of water can cause to the environment and aquatic life, and the effect that it can have on human skin and health, in general, especially if it penetrates into the human body and the bloodstream.